Reda Chappell

  • Additionally, our study includes a mixed population of patients treated mTOR inhibitors-based combination therapy or mTOR inhibitors alone, and patients received placebo or non-placebo therapy were also included in our study. Therefore, the treatment design is not the same in all arms, and it might be another source of heterogeneity. Finally, it…[Read more]

  • Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction because antiplatelet therapy for secondary Ethacrynic acid stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and aspirin…[Read more]

  • Reda Chappell posted an update 4 days ago

    Additionally, our study includes a mixed population of patients treated mTOR inhibitors-based combination therapy or mTOR inhibitors alone, and patients received placebo or non-placebo therapy were also included in our study. Therefore, the treatment design is not the same in all arms, and it might be another source of heterogeneity. Finally, it…[Read more]

  • Reda Chappell posted an update 4 days ago

    Moreover, the new definition of drug resistant epilepsy was failure of adequate trials of two tolerated and appropriately chosen and used AED schedules to achieve sustained seizure freedom. In all eligible studies, types of AEDs were also variable. Moreover, drug-response was defined as patients with no seizure for more than three times the…[Read more]

  • Reda Chappell posted an update 4 days ago

    Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction because antiplatelet therapy for secondary ML239 stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and aspirin demonstrated that…[Read more]

  • Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction because antiplatelet therapy for secondary stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and aspirin demonstrated that…[Read more]

  • The meta-analysis is a powerful statistical tool to estimate the A22 hydrochloride incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the…[Read more]

  • Moreover, the new definition of drug resistant epilepsy was failure of adequate trials of two tolerated and appropriately chosen and used AED schedules to achieve sustained seizure freedom. In all eligible studies, types of AEDs were also variable. Moreover, drug-response was defined as patients with no seizure for more than three times the…[Read more]

  • Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction because antiplatelet therapy for secondary stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and Darglitazone sodium salt aspirin…[Read more]

  • Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction Mps1-IN-2 because antiplatelet therapy for secondary stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and aspirin demonstrated…[Read more]

  • The meta-analysis is a powerful statistical tool to estimate the incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the first…[Read more]

  • Moreover, the new definition of drug resistant epilepsy was failure of adequate trials of two tolerated and appropriately chosen and used AED schedules to achieve sustained seizure freedom. In all eligible studies, types of AEDs were also variable. Moreover, drug-response was defined as patients with no seizure for more than three times the…[Read more]

  • The meta-analysis is a powerful statistical tool to estimate the incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the first…[Read more]

  • Moreover, the new definition of drug resistant epilepsy was failure of adequate trials of two tolerated and appropriately chosen and used AED schedules to achieve sustained seizure freedom. In all eligible studies, types of AEDs were also variable. Moreover, drug-response was defined as patients with no seizure for more than three times the…[Read more]

  • The meta-analysis is a powerful statistical tool to estimate the incidence and risk of those uncommon serious drug-related toxicities and this approach has been utilized to demonstrate an increased risk in treatment related mortality with bevacizumab and VEGFR-TKIs in previous researches. To the best of our knowledge, this is the first…[Read more]

  • Reda Chappell posted an update 2 weeks ago

    Additionally, our study includes a mixed population of patients treated mTOR inhibitors-based combination therapy or mTOR inhibitors alone, and patients received placebo or non-placebo therapy were also included in our study. Therefore, the treatment design is not the same in all arms, and it might be another source of heterogeneity. Finally, it…[Read more]

  • Reda Chappell posted an update 2 weeks ago

    Meanwhile, the potent anti-platelet activity of K-134 also make it a potential alternative agent for preventing secondary cerebral infarction because antiplatelet therapy for secondary stroke prevention has been proved to be beneficial in clinical trials. Moreover, a double-blind, randomized trial of cilostazol and aspirin demonstrated that…[Read more]

  • Diverse roles in disease development and progression have led MMPs to be regarded as promising therapeutic targets, resulting in development of many small-molecule MMP inhibitors, but clinical trials of early-generation MMP inhibitors in cancer and arthritis proved disappointing. Broad-spectrum MMP inhibitors produced serious dose-limiting…[Read more]

  • According to this perspective, in Ref., an abstract environment for TB case has been defined, where patients can occupy one of the five different states: No infection, New infection, Latency, Reactivation of a previous TB infection, Post first TB encounter. Clearly, the patients starting the therapy can correspond to either state or, because all…[Read more]

  • Studies on the pathogenic mechanisms of RA have revealed that tumor necrosis factor is a cytokine playing a critical role in the inflammatory cascade that results in the irreversible joint damage typical of the disease. Following these discoveries, a series of clinical trials in patients with RA showed the therapeutic benefit of TNF blockade. As a…[Read more]

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