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05). Survival rates and percentage of infants with normal renal function were significantly higher in the cystoscopic group than in the expectant group (p < 0.05). Percutaneous fetal cystoscopy is feasible using a thinner special cannula for prenatal diagnosis and therapy of LUTO. Prenatal laser ablation of the PUV under cystoscopy may prevent renal function deterioration improving postnatal outcome. Copyright © 2009 John Wiley & Sons, Ltd. “”What’s Already Known About This Topic? Adverse pregnancy outcomes associated with placental dysfunction is a leading cause of perinatal morbidity and mortality in the non-malformed fetus/newborn and also of maternal morbidity and mortality. They are also responsible for long-term effects on maternal and child/adult health. They encompass different clinical phenotypes for which Wortmannin solubility dmso the etiopathophysiology is far from being well understood. What does this study add? This study provides a written transcript to accompany an oral debate that was presented at the 18th International Conference on Prenatal Diagnosis and Therapy in Brisbane, Australia, on 22 July 2014. It provides different insights about the potential benefits of different approaches, proteomics and genomics, in the search for improving our knowledge in placental mediated APO. “”What’s already known about this topic? Coronary artery fistulas are rare anomalies with an incidence of 0.002% in the population. What does this study add? The association of tetralogy of Fallot, coronary artery fistulas, and agenesis of the ductus arteriosus has not been reported. The discrepancy between the narrow pulmonary annulus with thickened pulmonary valve and the large pulmonary trunk can be caused by extra blood supply through the large fistula. “”We sought to evaluate the influence of maternal body mass index (BMI) on sonographic detection employing data from the FaSTER trial. Unselected singleton pregnancies underwent detailed genetic sonogram to evaluate for structural fetal anomalies and soft markers for aneuploidy. BMI (kg/m2) were calculated from reported initial visit values. Sensitivity, specificity, false positive and false negative rates (FPR and FNR), likelihood ratio, detection rates, and a missed diagnosis rate (MDR: FNR + marker recorded as ‘missing’/N) were calculated. Eight thousand five hundred and fifty-five patients with complete BMI information had detailed genetic sonography. A lower sensitivity with an elevated FNR and MDR was observed in obese women for multiple aneuploid markers (e.g. ≥2 markers 32% sensitivity with 68% FNR among BMI 30). Similarly, the detection rate for cardiac anomalies among women at BMI <25 was higher (21.6%) at a significantly lower FPR (78.4%; 95% CI 77.3–79.5%) in comparison to obese women (8.3% with FPR 91.7%; 95% CI 90.1–93.2%). In a logistic regression model, maternal obesity significantly decreased the likelihood of sonographic detection of common anomalies (adjusted OR 0.